In summary, I would suggest infusing the IVIG at a slower rate, administering ml of IV saline following the infusion, and adding corticosteroid prior to the infusion 0. I would consider changing IV products or switching to a subcutaneous product. I have shared this response with Dr.
I would stay away from the IgA issue because the symptoms are vague. With IVIG these complaints are not uncommon. The management directions is as you stated: good hydration even prior to starting the infusion, perhaps steroids Solucortef mg , or try using a different product. Tolerability definitely a factor among patient preferences, but may not be easy to do with formulary issues.
Could break the IVIG into 3 week intervals with lower doses. Certain IVIG products can be safer for patients with prior existing kidney issues. Be sure to discuss any prior existing conditions with your pharmacist and physician. IVIG can be administered concurrently with many other therapies, some of which can be antibiotics.
However, certain antibiotics may need to be held or stopped during infusion days of IVIG to ensure complications do not arise. Be sure to discuss your concurrent therapies with your pharmacist and physician before beginning IVIG therapy.
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Search for: Search Button. Read the full article to learn more about what IVIG is, how it is administered, and other frequently asked questions. What is IVIG? A case in point: One patient who experienced anaphylaxis is a child named Julia. At 7 months old, Julia was diagnosed with pertussis, despite having been vaccinated. At age 5, she was diagnosed with a primary immune deficiency, and at age 6, IVIG treatments were started.
Unfortunately, her infusion days rarely went smoothly. From the beginning, Julia was plagued with flu-like symptoms, and by age 9, she experienced severe migraines lasting three days. Doctors treated Julia with Benadryl and prednisone prior to her infusions, as well as with intravenous Benadryl during her infusions. In addition, the rate of infusions was slowed down so much that they took eight hours to complete.
During the infusion, Julia felt her chest tightening and told her mother she was having trouble breathing. Overcome by an analphylactoid reaction, Julia went into respiratory arrest, so the doctors quickly stopped the infusion and administered valium and epinephrine. But, after weighing the risks and benefits, doctors successfully resumed therapy with the original brand of IVIG.
When Julia was 13, doctors suggested subcutaneous infusions in hopes of giving Julia her life-saving IG without risking her life. This worked; Julia was soon free of the side effects that plagued her with every treatment. Anaphylactic and anaphylactoid reactions both referred to as anaphylaxis are life-threatening events that result from an overreactive and misdirected immune response to a substance that is viewed by the body as foreign an antigen.
An anaphylactic reaction is an acute fatal, or potentially fatal, hypersensitivity reaction that requires the patient to be sensitized and their reaction mediated through immunoglobulin E IgE antibodies. Thus, an anaphylactic reaction occurs only after the patient has been previously exposed at least once to the antigen and is sensitized.
And, it can occur following a single, first-time exposure to certain agents in nonsensitized patients. Anaphylactic and anaphylactoid reactions to IVIG therapy are relatively rare, but they can occur in any patient at any time.
In kidney failure, the kidneys stop working properly. Kidney failure is most likely to happen in children who have had kidney problems before. This section does not apply to children getting regular IVIG for an antibody deficiency. If your child needs a vaccine after having IVIG, talk to your child's doctor about the best time to have it. Blood products, human immunoglobulin and timing of immunization: Canadian Immunization Guide.
Health Canada. Please speak with your child's health-care provider if you have concerns regarding their dosage. Disclaimer : The information in this Family Med-aid is accurate at the time of printing. It provides a summary of information about Intravenous Immunoglobulin IVIG and does not contain all possible information about this medicine.
Not all side effects are listed. If you have any questions or want more information about Intravenous Immunoglobulin IVIG , speak to your healthcare provider. Skip to main content. It looks like your browser does not have JavaScript enabled. Please turn on JavaScript and try again. Listen Focus. What is the medication. What is IVIG? IVIG is sometimes called Gamma. Before giving the medication. What is IVIG used for? How to give the medication. How long does it take to work.
How long does it take to work?
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